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Sanquin

PhD Candidate in Antibody Therapy for Bleeding Disorders Sanquin Blood Supply Foundation in Netherlands

Degree Level

PhD

Field of study

Computer Science

Funding

Full funding available

Deadline

Aug 28, 2026

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Country

Netherlands

University

Sanquin

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Keywords

Computer Science
Chemistry
Biomedical Engineering
Biology
Structural Biology
Synthetic Biology
Medical Science
Protein Engineering
Antibody Therapy
Bleeding Disorders

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About this position

Sanquin Blood Supply Foundation in Amsterdam, Netherlands is recruiting a PhD candidate for a 4-year project on antibody therapy for bleeding disorders. The work sits in Sanquin’s Division of Research and Lab Services and is embedded in a multidisciplinary team spanning protein engineering, immunoglobulin research, cellular hemostasis, and proteomics.

The project aims to develop coagulation factor mimetics using novel antibody formats that can arrest bleeding. Research topics include computational de novo design of VHH and scFv binders to coagulation factors such as factor Xa and prothrombin, wet-lab production and screening of binders, optimization of heterobispecific Fc formats with a focus on humanization and stability, and generation of high-affinity minibinders through in silico affinity maturation.

Supervision and collaboration involve Dr. Matti Pronker, Prof. Gestur Vidarsson, Prof. Jan Voorberg, and Dr. Maartje van den Biggelaar at Sanquin in Amsterdam. The post is especially suitable for candidates with experience in AI-based protein design and/or structural biology, and it is framed as a translational synthetic biology project in an international, academically oriented environment.

Funding and benefits include salary and conditions according to CAO Sanquin, an end-of-year bonus, partial travel reimbursement, pension coverage, and leave entitlement. The application deadline is 28 August 2026 at 21:59 UTC, and applicants are asked to submit an extended CV via the AcademicTransfer application page.

Funding details

Full funding including tuition fees and living expenses is available for this position. The scholarship covers all educational costs and provides a monthly stipend.

How to apply

Please submit your application including a cover letter, CV, academic transcripts, and contact information for two references. Applications should be sent via the online portal before the deadline.

More information can be found here

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