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University of Cambridge

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PhD in Cell-Type Specific RNA Processing Defects in Neurodegeneration University of Cambridge in United Kingdom

Degree Level

PhD

Field of study

Computer Science

Funding

Full funding available

Deadline

Dec 8, 2026

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Country

United Kingdom

University

University of Cambridge

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Keywords

Computer Science
Biology
Computational Biology
Neuropsychology
Medical Science
Rna Editing
Neurodegenerative Disease
Long-read Sequencing
Statistics
Spatial Transcriptomic

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About this position

PhD opportunity at the University of Cambridge in cell-type specific RNA processing defects in neurodegeneration.

This project, hosted by the Department of Clinical Neurosciences and linked to the Ryten Lab, focuses on how RNA processing changes in vulnerable brain cell populations contribute to neurodegenerative disease. The research is centered on Parkinson’s disease, Lewy body dementia, and Alzheimer’s disease, with emphasis on RNA splicing, transcript isoform use, RNA editing, and 3′ untranslated region usage.

The student will work with human brain transcriptomic data, including single-nucleus RNA sequencing, spatial transcriptomics, short-read RNA sequencing, and long-read RNA sequencing. The project aims to identify disease-associated RNA-processing events and RNA-binding proteins, integrate transcriptomic data with genetic and cellular information, and prioritize biomarkers or therapeutic targets. Depending on interests and skills, the work may include computational biology, development of reproducible pipelines, and experimental validation in human tissue or iPSC-derived cellular models.

Funding: This is a competition-funded PhD project. The post notes funding deadlines for Gates US and Cambridge Trust / Gates Cambridge. Applicants should ensure they apply before the relevant funding deadline and indicate all funding they are eligible for.

Location: Cambridge, United Kingdom.

Application: Register your interest via the FindAPhD listing and follow the University of Cambridge application process. Review the funding deadlines carefully before applying.

Funding details

Full funding including tuition fees and living expenses is available for this position. The scholarship covers all educational costs and provides a monthly stipend.

How to apply

Please submit your application including a cover letter, CV, academic transcripts, and contact information for two references. Applications should be sent via the online portal before the deadline.

More information can be found here

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