Oscar P. Kuipers

University of Groningen

Netherlands

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Research Interests

Biochemistry

100%

Pharmaceutical Chemistry

70%

Natural Product Synthesis

80%

Protein Chemistry

80%

Antimicrobial Research

70%

Chemical Biology

70%

Antimicrobial Peptide

60%

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Articles31

Design and Production of Geranylated Cyclic Peptides by the RiPP Enzymes SyncM and PirF

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Year:

2025

Genetic Code Expansion for Controlled Surfactin Production in a High Cell-Density Bacillus subtilis Strain

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Year:

2025

Functionalizing Nisin with a Sugar Moiety Improves Its Solubility and Results in an Altered Antibacterial Spectrum and Mode of Action

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Year:

2025

Synthesis and Antimicrobial Specificities of Halogenated Tryptophan-Containing Nisin Variants

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Year:

2025

Insight into the epigenetic regulation of gene expression in the bloodstream and procyclic forms of Trypanosoma brucei through the involvement of G-quadruplexes

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Year:

2025

Design and Biosynthesis of Ornithine 8-Containing Semaglutide Variants with a Click Chemistry-Modifiable Position 26

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Year:

2025

Heterologous Expression and Characterization of Estercin A, a Class II Lanthipeptide Derived from Clostridium estertheticum CF016, with Antimicrobial Activity against Clinically Relevant Pathogens

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Year:

2025

Synechococsins

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Year:

2025

Rombocin, a Short Stable Natural Nisin Variant, Displays Selective Antimicrobial Activity against <i>Listeria monocytogenes</i> and Employs a Dual Mode of Action to Kill Target Bacterial Strains

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Year:

2024

Selective Aza-Michael Addition to Dehydrated Amino Acids in Natural Antimicrobial Peptides

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Year:

2024

Enhancing food preservation and safety

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Year:

2024

An Engineered Nisin Analogue with a Hydrophobic Moiety Attached at Position 17 Selectively Inhibits Enterococcus faecium Strains

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Year:

2024

Discovery, Biosynthesis, and Characterization of Rodencin, a Two-Component Lanthipeptide, Harboring d-Amino Acids Introduced by the Unusual Dehydrogenase RodJA

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Year:

2024

A systematic comparison of natural product potential, with an emphasis on RiPPs, by mining of bacteria of three large ecosystems

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Year:

2024

Facile Halogenation of Antimicrobial Peptides As Demonstrated by Producing Bromotryptophan-Labeled Nisin Variants with Enhanced Antimicrobial Activity

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Year:

2024

Identification of metabolites produced by six gut commensal Bacteroidales strains using non-targeted LC-MS/MS metabolite profiling

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Year:

2024

Temperature dependence of the mutation rate towards antibiotic resistance

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Year:

2024

A two-step regulatory circuit involving Spo0A-AbrB activates mersacidin biosynthesis in Bacillus subtilis

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Year:

2024

Engineering hybrid lantibiotics yields the highly stable and bacteriocidal peptide cerocin V

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Year:

2024

In Vitro Influence of Specific Bacteroidales Strains on Gut and Liver Health Related to Metabolic Dysfunction-Associated Fatty Liver Disease

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Year:

2024

Biosynthesis of Antimicrobial Ornithine-Containing Lacticin 481 Analogues by Use of a Combinatorial Biosynthetic Pathway in Escherichia coli

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Year:

2024

Synthesis and antimicrobial activity of aminoalkyl resveratrol derivatives inspired by cationic peptides

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Year:

2023

Emulating nonribosomal peptides with ribosomal biosynthetic strategies

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Year:

2023

Seeing the Invisibles: Detection of Peptide Enantiomers, Diastereomers, and Isobaric Ring Formation in Lanthipeptides Using Nanopores

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Year:

2023

Lipidated variants of the antimicrobial peptide nisin produced via incorporation of methionine analogs for click chemistry show improved bioactivity

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Year:

2023

Engineering lanthipeptides by introducing a large variety of RiPP modifications to obtain new-to-nature bioactive peptides

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Year:

2023

Cell‐to‐cell non‐conjugative plasmid transfer between Bacillus subtilis and lactic acid bacteria

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Year:

2023

Leader- and Terminal Residue Requirements for Circularin A Biosynthesis Probed by Systematic Mutational Analyses

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Year:

2023

Investigating the Specificity of the Dehydration and Cyclization Reactions in Engineered Lanthipeptides by Synechococcal SyncM

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Year:

2023

Emulating nonribosomal peptides with ribosomal biosynthetic strategies

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Year:

2022

Functional production of clostridial circularin A in Lactococcus lactis NZ9000 and mutational analysis of its aromatic and cationic residues

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Year:

2022

Collaborators14

Franz J. Weissing

Professor of Theoretical Biology

Rijksuniversiteit Groningen

NETHERLANDS

Silja Mordhorst

University of Tübingen

GERMANY

Fangfang Liu

University of Groningen

NETHERLANDS

Gerard Roelfes

University of Groningen

NETHERLANDS

Sahar El Aidy

Professor of Host-microbe metabolic interactions

Rijksuniversiteit Groningen Faculty of Science and Engineering

NETHERLANDS

M. VIOLANTE DE PAZ

Profesor Titular de Universidad

Universidad de Sevilla

SPAIN

Patricia Arias-Orozco

Technical University of Denmark

DENMARK

Alberto Baños-Arjona

Universidad de Granada

SPAIN

Ricardo Lucas

Profesor Permanente Laboral

Universidad de Sevilla

SPAIN

Siewert J. Marrink

University of Groningen

NETHERLANDS

Ambrin Farizah Babu

University of Turku

FINLAND

Eric Hiller

University of Hohenheim

GERMANY

Fleur Ruijne

University of Groningen

NETHERLANDS

Rudolf Hausmann

GERMANY

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